Patients with diabetes have a 40% higher risk of developing atrial fibrillation, compared to people who do not have diabetes, according to a study published in the Journal of General Internal Medicine. The study was carried out by Dr. Sarcha Dublin and team of Group Health Research Institute. The scientists also found that atrial fibrillation risk is greater the longer people have diabetes, and the less controlled their blood sugar is.
As the American population continues ageing and gaining weight, diabetes is becoming more prevalent.
For three years, Dr. Dublin and her colleagues tracked more than 1,400 Group Health patients who had newly recognized atrial fibrillation. They compared these cases with more than 2,200 controls. The controls were matched to the cases by age, sex, year, and whether they were treated for high blood pressure; but unlike the cases, they had no atrial fibrillation.
This was the first study to examine the relationship between atrial fibrillation and the duration of patients' diabetes and their blood sugar levels. Unlike most previous studies, this one also adjusted for patients' weight, which is important because both diabetes and atrial fibrillation are more common in heavier people. The study found that:
Patients with diabetes were 40% more likely to be diagnosed with atrial fibrillation than other people.
The risk of atrial fibrillation rose by 3% for each additional year that patients had diabetes.
For patients with high blood sugar (glycosylated hemoglobin, also known as HBA1c more than 9 percent), the risk of atrial fibrillation was twice that for people without diabetes.
But patients with well-controlled diabetes (HBA1c 7 percent or less) were about equally likely to have atrial fibrillation as people without diabetes.
Dr. Dublin said "When a patient with diabetes has symptoms like heart palpitations, clinicians should have a higher level of suspicion that the reason could be atrial fibrillation. This heart rhythm disturbance is important to diagnose, because it can be treated with medications like warfarin that can prevent many of the strokes that the atrial fibrillation would otherwise cause."
It is hard to establish which comes first - diabetes or atrial fibrillation - with this kind of case-control study, unlike a randomized trial, Dr. Dublin said. "But our finding that the risk of atrial fibrillation is higher with longer time since patients started medications for diabetes, and with higher blood glucose levels, is strongly suggestive that diabetes can cause atrial fibrillation." She used time since starting diabetes medication as a measure of how long patients had the disease.
The study was funded through a Veterans' Affairs Health Services Research & Development fellowship and a Paul Beeson Career Development Award from the National Institute on Aging. The Beeson Award is also supported in part by the American Federation for Aging Research, the Hartford Foundation, the Atlantic Philanthropies and the Starr Foundation. The National Heart, Lung, and Blood Institute funds the Heart and Vascular Health Study, which collects data on Group Health patients newly diagnosed with atrial fibrillation and other cardiovascular conditions. The study of atrial fibrillation, led by Dr. Dublin's co-author Dr. Susan Heckbert, aims to find new factors that raise the risk of developing this quivering of the heart's upper chambers (atria).
About 1 in 100 people - and nearly 9 in 100 people over age 80 - have atrial fibrillation, according to Dr. Heckbert, a professor of epidemiology and scientific investigator in the Cardiovascular Health Research Unit at the University of Washington (UW) and an affiliate investigator at Group Health Research Institute. In many cases, atrial fibrillation has no symptoms, and it is not necessarily life threatening. But it can cause palpitations, fainting, fatigue, or congestive heart failure. Atrial fibrillation can also make blood pool - and sometimes clot - in the atria. When parts of clots break off and leave the atria, they can lead to embolic strokes, as happens in more than 70,000 Americans a year.
Other co-authors were Group Health Research Institute Senior Investigator Bruce M. Psaty, MD, PhD, who co-directs the UW's Cardiovascular Health Research Unit; and Nicole L. Glazer, PhD, Thomas Lumley, PhD, Kerri L. Wiggins, MS, RD, of the UW; Nicholas L. Smith, PhD, of the UW and Veterans Affairs Puget Sound Health Care System; and Richard L. Page, MD, of the University of Wisconsin School of Medicine and Public Health in Madison.
"Diabetes Mellitus, Glycemic Control, and Risk of Atrial Fibrillation"
Sascha Dublin, Nicole L. Glazer, Nicholas L. Smith, Bruce M. Psaty, Thomas Lumley, Kerri L. Wiggins, Richard L. Page and Susan R. Heckbert
Journal of General Internal Medicine
DOI: 10.1007/s11606-010-1340-y
View abstract online
View drug information on Warfarin Sodium tablets.
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